At the end of this chapter, the learner will be able to:
Describe the sequence of normal acute wound healing.
Identify the cells that direct activity in the healing cascade.
Describe the chemical messengers necessary for timely wound healing (including the cells of origin, target cells, and actions).
Classify the primary enzymes produced during healing (including the cells of origin and actions).
Explain the differences between normal acute and chronic wound healing.
Relate the pharmacological impact of common drugs on the healing phases.
Perhaps the hamartia, or the flaw, in the study of wound healing is the tendency to oversimplify the truly elegant system that ensures healing, both anatomically and functionally. The multitude of processes that ensure wound closure and the commensurate return of function are equally marvelous.
The following illustrations introduce the interplay of cellular and molecular signaling in conjunction with vascular events that occur in concert during the healing process. The figures demonstrate how cells involved in the repair process are directed, based upon global and local stimuli. The stimuli may be cytokine, chemokine, pH, or galvanically driven.1,2 If invaders or pathogens (eg, bacteria, fungi, viruses, or debris) are present, innate immune cells migrate and proliferate to the site of injury.3 These cells include macrophages, neutrophils, natural killer (NK) cells, and gamma delta T cells. If the invader is a repeat offender that the host has successfully fended off previously, adaptive immune responses (B cell clonal expansion) are triggered.3-5 Simultaneously, debris (necrotic and/or injured cells) is removed and a new wound bed excavated via proteases and extracellular matrix (ECM) degradation. This serves two purposes: (1) the clearance of cell and invader refuse and (2) the provision of pathways for cellular migration and proliferation, which constitute repair.2
The signaling in wound healing, renewal, and regeneration is a product of many factors, including the concentration and timing of chemical signal delivery, target cell receptor availability, active form after cleavage, degradation rate, messenger half-life, pH and presence of enzymes (eg, proteases) in the wound milieu, hydrophobicity, and hydrophyllicity. Scaffold-binding (via heparin activation or other mechanisms), fiber type (whether fibrin or collagen), cell shape, adhesion interfaces (via integrins), and storage of growth factors all contribute to the timing and intensity of cell signaling during wound healing. These factors work together to drive growth factor, cytokine, and chemokine bioavailability, thus resulting in wound healing.
Vascular changes occur as a result of endothelial cell activation, migration, and capillary expansion in response to tissue hypoxia and increased lactic acid concentration.6-8 These responses, along with the appropriate cells and signaling mechanisms, are depicted in TABLE 2-1.
Important Cells in Wound Healing
Log In to View More
If you don't have a subscription, please view our individual subscription options below to find out how you can gain access to this content.
Want remote access to your institution's subscription?
Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.
If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.
AccessPhysiotherapy Full Site: One-Year Subscription
Connect to the full suite of AccessPhysiotherapy content and resources including interactive NPTE review, more than 500 videos, Anatomy & Physiology Revealed, 20+ leading textbooks, and more.
Pay Per View: Timed Access to all of AccessPhysiotherapy
24 Hour Subscription $34.95
48 Hour Subscription $54.95
Pop-up div Successfully Displayed
This div only appears when the trigger link is hovered over.
Otherwise it is hidden from view.