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CONDITION/DISORDER SYNONYM

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  • Severe combined immunodeficiency (SCID)

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ICD-9-CM CODES

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  • 279.06 Common variable immunodeficiency

  • 279.2 Combined immunity deficiency

  • Associated ICD-9-CM PT diagnoses/treatment diagnosis that may be directly related

    • 315.4 Developmental coordination disorder

    • 718.45 Contracture of joint, pelvic region and thigh

    • 719.70 Difficulty in walking involving joint site unspecified

    • 728.2 Muscular wasting and disuse atrophy, not elsewhere classified

    • 728.89 Other disorders of muscle, ligament, and fascia

    • 729.9 Other and unspecified disorders of soft tissue

    • 780.7 Malaise and fatigue

    • 781.2 Abnormality of gait

    • 782.3 Edema

    • 786.0 Dyspnea and respiratory abnormalities

    • 786.05 Shortness of breath

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ICD-10-CM CODES

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  • D81.0 Severe combined immunodeficiency (SCID) with reticular dysgenesis

  • D81.1 Severe combined immunodeficiency (SCID) with low T- and B-cell numbers

  • D81.2 Severe combined immunodeficiency (SCID) with low or normal B-cell numbers

  • D81.89 Other combined immunodeficiencies

  • D81.9 Combined immunodeficiency, unspecified

  • D83.8 Other common variable immunodeficiencies

  • D83.9 Common variable immunodeficiency, unspecified

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FIGURE 48-1

T cell differentiation, effector pathways, and related primary immunodeficiencies (PIDs). Hematopoietic stem cells (HSCs) differentiate into common lymphoid progenitors (CLPs), which, in turn, give rise to the T cell precursors that migrate to the thymus. The development of CD4+ and CD8+ T cells is shown. Known T cell effector pathways are indicated, that is, γδ cells, cytotoxic T cells (Tc), TH1, TH2, TH17, TFh (follicular helper) CD4 effector T cells, regulatory T cells (Treg), and natural killer T cells (NKTs); abbreviations for PIDs are contained in boxes. Vertical bars indicate a complete deficiency; broken bars a partial deficiency. SCID, severe combined immunodeficiency; ZAP 70, zeta-associated protein deficiency, MHCII, major histocompatibility complex class II deficiency; TAP, TAP1 and 2 deficiencies; Orai1, Stim1 deficiencies; HLH, hematopoietic lymphohistiocytosis; MSMD, Mendelian susceptibility to mycobacterial disease; Tyk2, DOCK8, autosomal recessive form of hyper-IgE syndrome; STAT3, autosomal dominant form of hyper-IgE syndrome; CD40L, ICOS, SAP deficiencies; IPEX, immunodysregulation polyendocrinopathy enteropathy X-linked syndrome; XLP, X-linked proliferative syndromes. (From Longo DL, Fauci AS, Kasper DL, Hauser SL, JamesonJL, Loscalzo J, eds. Harrison’s Principles of Internal Medicine. 18th ed. New York, NY: McGraw-Hill; 2012.)

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FIGURE 48-2

General approach to primary immunodeficiencies. (From Hay WM, et al. Current Diagnosis & Treatment: Pediatrics, 21st ed. New York, NY: McGraw-Hill. www.accessmedicine.com. Copyright © The McGraw-Hill Companies, Inc. All rights reserved.)

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PREFERRED PRACTICE PATTERNS1

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  • Note: The APTA Guide to Physical Therapist Practice includes practice patterns for neuromuscular and musculoskeletal systems; as primary immunodeficiency is medical in nature, the practice patterns addressed are those for associated disorders that may occur and impair aerobic capacity.

  • 4D: Impaired Joint Mobility, Motor Function, Muscle Performance, and Range of Motion Associated with Connective Tissue Dysfunction

  • 4E: Impaired Joint Mobility, Motor Function, Muscle Performance, and Range of Motion Associated with Localized Inflammation

  • 6B: ...

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