Adult pseudohypertrophic muscular dystrophy
Becker muscular dystrophy
Benign X-linked recessive muscular dystrophy
Childhood pseudohypertrophic muscular dystrophy
Duchenne muscular dystrophy
PREFERRED PRACTICE PATTERN3
“A 3-year-old boy is brought to his pediatrician to be evaluated for difficulty walking and clumsiness. According to his parents, the patient began walking at the age of 18 months, but in the past year he has begun to fall more frequently and has difficulty getting up from the floor; often supporting himself with his hands along the length of his legs. Birth and developmental history until symptom onset are reportedly normal. There is no contributing family history.
On physical examination the young boy has significant muscle weakness of his hip flexors, knee extensors, deltoids, and biceps muscles. His calves are large, and he walks on his toes during ambulation. Laboratory studies reveal an elevated serum creatine kinase (CK) level of greater than 900 international units per liter (IU/L). Electromyography (EMG) of his muscles reveals a myopathy. Nerve conduction studies reveal relative normal nerve function.4
Group of genetic disorders that result in progressive muscle weakness due to loss of myofibrils5
Causes defects in muscle proteins: Weakens the musculoskeletal system
Muscle cell and tissue death
Nine major types of muscular dystrophy (MD)
Diagnosed through molecular characteristics
Diagnosis is dependent on
Summary of mechanisms involved in the causation of Duchenne muscular dystrophy (OMIM 310200). (From Murray RK, Bender D, Botham KM, et al. Harper’s Illustrated Biochemistry. 29th ed. www.accessmedicine.com. Copyright © The McGraw-Hill Companies, Inc. All rights reserved.)
Log In to View More
If you don't have a subscription, please view our individual subscription options below to find out how you can gain access to this content.
Want remote access to your institution's subscription?
Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.
If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.
AccessPhysiotherapy Full Site: One-Year Subscription
Connect to the full suite of AccessPhysiotherapy content and resources including interactive NPTE review, more than 500 videos, Anatomy & Physiology Revealed, 20+ leading textbooks, and more.
Pay Per View: Timed Access to all of AccessPhysiotherapy
24 Hour Subscription $34.95
48 Hour Subscription $54.95
Pop-up div Successfully Displayed
This div only appears when the trigger link is hovered over.
Otherwise it is hidden from view.