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CHAPTER 8: Basal Nuclei

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Injury to which of the basal nuclei is associated with Huntington's disease?

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A. The striatum

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B. The subthalamic nucleus

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C. The substantia nigra pars compacta

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D. The globus pallidus internus

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A. The striatum

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The most well-known and best-studied basal nuclei circuit is the:

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A. associative loop.

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B. motor loop.

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C. visual loop.

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D. limbic loop.

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B. motor loop.

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Developmentally, which nuclei are most closely related?

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A. The substantia nigra pars compacta and the globus pallidus externa

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B. The putamen and the subthalamic nucleus

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C. The substantia nigra pars reticularis and the globus pallidus interna

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D. The caudate and the subthalamic nucleus

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C. The substantia nigra pars reticularis and the globus pallidus interna

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Output from the subthalamic nucleus:

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A. is inhibitory to the globus pallidus externa.

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B. is excitatory to the striatum.

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C. is inhibitory to the thalamus.

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D. is excitatory to the globus pallidus interna.

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D. is excitatory to the globus pallidus interna.

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Loss of which neurotransmitter is associated with Parkinson's disease?

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A. Serotonin

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B. Glutamate

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C. Dopamine

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D. GABA

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C. Dopamine

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Lesions in the basal nuclei:

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A. produce tremors on intention.

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B. produce contralateral deficits.

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C. produce only motor deficits.

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D. produce ataxia, tremor, and nystagmus.

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B. produce contralateral deficits.

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Which of the following statements concerning the direct and indirect basal nuclei pathways is correct?

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A. The indirect pathway reduces movement and “selects” meaningful motor activity.

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