Skip to Main Content

++

  • Transmissible spongiform encephalopathies (TSEs)
  • Creutzfeldt-Jakob disease (CJD)
  • Variant Creutzfeldt-Jakob disease (vCJD)
  • Kuru
  • Fatal familial insomnia
  • Gerstmann-Straussler-Scheinker syndrome

++

  • 046.0 Kuru
  • 046.1 Jakob-Creutzfeldt disease
  • 046.11 Variant Creutzfeldt-Jakob disease
  • 046.19 Other and unspecified Creutzfeldt-Jakob disease
  • 046.2 Subacute sclerosing panencephalitis
  • 046.3 Progressive multifocal leukoencephalopathy
  • 046.7 Other specified prion diseases of central nervous system
  • 046.71 Gerstmann-Sträussler-Scheinker syndrome
  • 046.72 Fatal familial insomnia
  • 046.79 Other and unspecified prion disease of central nervous system
  • 046.8 Other specified slow virus infection of central nervous system
  • 046.9 Unspecified slow virus infection of central nervous system

++

  • A81.00 Creutzfeldt-Jakob disease, unspecified
  • A81.01 Variant Creutzfeldt-Jakob disease
  • A81.09 Other Creutzfeldt-Jakob disease
  • A81.1 Subacute sclerosing panencephalitis
  • A81.2 Progressive multifocal leukoencephalopathy
  • A81.81 Kuru
  • A81.82 Gerstmann-Sträussler-Scheinker syndrome
  • A81.83 Fatal familial insomnia
  • A81.89 Other atypical virus infections of central nervous system
  • A81.9 Atypical virus infection of central nervous system, unspecified

++
++

Description

++

  • Progressive neurodegenerative disorder
  • Abnormal pathogenic agent
  • Leads to brain damage
  • Affects the central nervous system
  • Rapidly progressive and fatal
  • Three classifications
    • Sporadic
    • Familial
    • Acquired

++

Essentials of Diagnosis

++

  • Presence of microscopic vacuolization of the brain tissue, spongy

++

General Considerations

++

  • Can affect both humans and animals
  • Currently no cure, fatal

++

Demographics

++

  • Familial type is genetic: defect in the prion protein gene

++

Signs and Symptoms

++

  • Dementia
  • Convulsions
  • Ataxia
  • Behavior or personality changes

++

Functional Implications

++

  • Inability to perform ADLs independently
  • Inability to perform functional mobility independently
  • Inability to perform cognitive tasks appropriate to age and educational level
  • Inability to execute fine and gross motor tasks independently

++

Possible Contributing Causes

++

  • Increased risk
    • Immunosuppressed
    • Perinatal to early childhood period
  • Prior meningitis

++

Differential Diagnosis

++

  • Stroke
  • Subdural empyema
  • Cerebral abscess
  • Cerebral venous thrombosis
  • Septic embolism
  • Meningitis

++

Laboratory Tests

++

++

Imaging

++

  • CT scan for detailed imaging
  • MRI

++

++

  • Emergency room if encephalitis is suspected
  • Neurologist both during infection and for follow-up
  • Social work and case management

++

  • Arousal
  • Attention
  • Behavior
  • Cognition
  • Cranial nerve integrity
  • Gait
  • Sitting and standing balance
  • Muscle strength
  • Postural control
  • Range of motion
  • Deep tendon reflexes
  • Muscle tone
  • Sensation
  • Bed ...

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.

Ok

About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Subscription Options

AccessPhysiotherapy Full Site: One-Year Subscription

Connect to the full suite of AccessPhysiotherapy content and resources including interactive NPTE review, more than 500 videos, Anatomy & Physiology Revealed, 20+ leading textbooks, and more.

$595 USD
Buy Now

Pay Per View: Timed Access to all of AccessPhysiotherapy

24 Hour Subscription $34.95

Buy Now

48 Hour Subscription $54.95

Buy Now

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.