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  • 191.7 Malignant neoplasm of brain stem
  • 191.8 Malignant neoplasm of other parts of brain
  • 191.9 Malignant neoplasm of brain, unspecified
  • 198.3 Secondary malignant neoplasm of brain and spinal cord
  • 225.0 Benign neoplasm of brain
  • 237.5 Neoplasm of uncertain behavior of brain and spinal cord
  • 239.6 Neoplasm of unspecified nature of brain
  • V10.85 Personal history of malignant neoplasm of brain
  • V12.41 Personal history of benign neoplasm of the brain

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  • C71.7 Malignant neoplasm of brain stem
  • C71.8 Malignant neoplasm of overlapping sites of brain
  • C71.9 Malignant neoplasm of brain, unspecified
  • C79.31 Secondary malignant neoplasm of brain
  • D33.0 Benign neoplasm of brain, supratentorial
  • D33.1 Benign neoplasm of brain, infratentorial
  • D33.2 Benign neoplasm of brain, unspecified
  • D43.0 Neoplasm of uncertain behavior of brain, supratentorial
  • D43.1 Neoplasm of uncertain behavior of brain, infratentorial
  • D43.2 Neoplasm of uncertain behavior of brain, unspecified
  • D49.6 Neoplasm of unspecified behavior of brain
  • H47.631 Disorders of visual cortex in (due to) neoplasm, right side of brain
  • H47.632 Disorders of visual cortex in (due to) neoplasm, left side of brain
  • Z85.841 Personal history of malignant neoplasm of brain
  • Z86.011 Personal history of benign neoplasm of the brain

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Description

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Essentials of Diagnosis

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  • Classic triad2
    • Morning headache
    • Vomiting
    • Papilledema
  • Breast, lung, melanoma, and renal cell cancers are most likely to metastasize to brain tissue
  • Tumor can occur in any part of the brain; symptoms help identify location of tumor prior to diagnostic imaging
  • Confirmation is commonly done by stereotactic biopsy or craniotomy

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General Considerations

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  • Secondary metastatic deposits are more common in adults than in children
  • Frequency and location of pediatric brain tumors
    • Posterior fossa—most common frequency and location of pediatric brain tumors2
  • AIDS, neurofibromatosis, and systemic cancers predispose the patient to development of a tumor in the nervous system
  • Growth rates and invasiveness vary
    • Glioblastomas are highly malignant and invasive
    • Meningiomas are benign and slowly progressive

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Demographics

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  • Approximately 20,000 people die annually in the United States from a malignant glioma
  • Approximately 130,000 people who die with cancer have evidence of metastases to the brain
  • In children, primary brain tumors constitute the most common solid tumor and represent 25% to 30% of childhood neoplasms2
  • Medulloblastomas, spongioblastomas, optic nerve gliomas, and pinealomas occur most frequently before age 20
  • Meningiomas and glioblastomas occur more frequently after age 50
  • Glioblastomas occur ...

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