TY  - CHAP
M1  - Book, Section
TI  - Chapter 16. Local Anesthetics
A1  - Panus, Peter C.
A1  - Jobst, Erin E.
A1  - Masters, Susan B.
A1  - Katzung, Bertram
A1  - Tinsley, Suzanne L.
A1  - Trevor, Anthony J.
PY  - 2009
T2  - Pharmacology for the Physical Therapist
AB  - Local  anesthesia  is  the  condition  that  results  when  sensory  transmission  from  a  local  area  of  the  body  to  the  central  nervous  system  (CNS)  is  blocked.  The  local  anesthetics  constitute  a  group  of  chemically  similar  agents  that  block  the  sodium  channels  of  excitable  membranes.  Because  these  drugs  can  be  administered  by  topical  application  or  by  injection  in  the  target  area,  the  anesthetic  effect  can  be  restricted  to  a  localized  area  (e.g.,  cornea,  arm,  foot).  Even  when  these  drugs  are  given  in  the  vicinity  of  the  spinal  cord,  it  is  still  considered  a  form  of  local  anesthesia  because  only  a  specific  level  of  cord  impulse  transmission  is  blocked.  When  given  intravenously,  however,  these  drugs  can  have  effects  on  other  tissues.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/20
UR  - accessphysiotherapy.mhmedical.com/content.aspx?aid=6092198
ER  -