RT Book, Section A1 Chandrasoma, Parakrama A1 Taylor, Clive R. SR Print(0) ID 184085 T1 Chapter 9. Abnormalities of Blood Supply T2 Concise Pathology, 3e YR 1998 FD 1998 PB The McGraw-Hill Companies PP New York, NY SN 9780838514993 LK accessphysiotherapy.mhmedical.com/content.aspx?aid=184085 RD 2024/04/24 AB The maintenance of adequate blood circulation is a highly complex process that depends on proper function of the heart, the integrity of the vasculature, and the maintenance of a delicate balance between the coagulation and fibrinolytic systems. Failure of blood supply to a tissue (ischemia) may be localized, due to arterial obstruction or deficient venous drainage, leading to infarction (ischemic necrosis of tissue); or generalized, due to severe decrease in cardiac output, leading to a generalized decrease in tissue perfusion (shock).