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ICD-9-CM Codes

  • 279.06 Common variable immunodeficiency

  • 279.2 Combined immunity deficiency

Associated ICD-9-CM PT diagnoses/treatment diagnosis that may be directly related

  • 315.4 Developmental coordination disorder

  • 718.45 Contracture of joint, pelvic region, and thigh

  • 719.70 Difficulty in walking involving joint site unspecified

  • 728.2 Muscular wasting and disuse atrophy, not elsewhere classified

  • 728.89 Other disorders of muscle, ligament, and fascia

  • 729.9 Other and unspecified disorders of soft tissue

  • 780.7 Malaise and fatigue

  • 781.2 Abnormality of gait

  • 782.3 Edema

  • 786.0 Dyspnea and respiratory abnormalities

  • 786.05 Shortness of breath

ICD-10-CM Codes

  • D83.8 Other common variable immunodeficiencies

  • D83.9 Common variable immunodeficiency, unspecified

  • D81.0 Severe combined immunodeficiency (SCID) with reticular dysgenesis

  • D81.1 Severe combined immunodeficiency (SCID) with low T- and B-cell numbers

  • D81.2 Severe combined immunodeficiency (SCID) with low or normal B-cell numbers

  • D81.89 Other combined immunodeficiencies

  • D81.9 Combined immunodeficiency, unspecified

Preferred Practice Patterns1

Key Features


  • Failure of the body to provide defense against bacterial or viral invasion as there is no or insufficient production of antibodies

  • There are 70 to 100 types in approximately six categories

  • Primary immunodeficiency disorders

  • Congenital immunodeficiency diseases

  • B-cell (antibody) deficiencies

  • T-cell deficiencies

  • Combination B- and T-cell deficiencies

  • Defective phagocytes

  • Complement deficiencies

  • Unknown (idiopathic)

  • Severe combined immunodeficiency (SCID) (bubble boy disease) is considered the most severe form of the disease

    • Chronic infections

    • Frequent infections

    • Multiple body-system involvement

    • Onset often vague with misdiagnosis of underlying disease

Essentials of Diagnosis

  • Must be made by a physician and confirmed by medical diagnostic testing

  • Warning signs of primary immunodeficiency

    • Eight or more new ear infections within one year

    • Two or more serious sinus infections within one year

    • Two or more months on antibiotics with little effect

    • Two or more pneumonias within one year

    • Failure of an infant to gain weight or grow normally

    • Recurrent, deep skin or organ abscesses

    • Persistent thrush in mouth or elsewhere on skin, after age one

    • Need for intravenous antibiotics to clear infections

    • Two or more deep-seated infections such as sepsis, meningitis, or cellulitis

    • A family history of primary immune deficiency

  • Frequent/recurrent Infections

  • Blood infections

  • Inflammation of internal organs: liver, spleen, pancreas

  • Autoimmune disorders

  • Blood disorders

  • Digestive problems

  • Delayed growth and development

  • Genetic factors

  • Abscessed wounds

  • Ineffective use of antibiotics

General Considerations


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