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Condition/Disorder Synonym

  • Osteitis deformans

ICD-9-CM Code

  • 731.0 Osteitis deformans without mention of bone tumor

ICD-10-CM Code

  • M88.9 Osteitis deformans of unspecified bone

Preferred Practice Patterns

Key Features


  • Osteometabolic bone disease

  • Excessive reabsorption of bone by osteoclasts, followed by vascular and fibrous tissue filling in the bone marrow

  • Weakening of the bones

  • Slow progressive enlargement of the bones

  • Accelerated bone remodeling

Essentials of Diagnosis

  • Phase 1: Osteolytic phase

    • Prominent bone reabsoprtion

  • Phase 2: Sclerotic phase

    • Decreased cellular activityoth

  • Phase 3: Mixed phased

    • Both active bone reabsorption and bone formation

General Considerations

  • Can be asymptomatic

  • Managed with surgery or medicine

  • Pathologic fractures

  • Can cause paraplegia or stenosis

  • Paget's disease of the nipple

    • Chronic rash on the nipple


  • More common with elderly, aging population

  • Individuals with absorption issues in the intestines

  • Men > women

  • Anglo-Saxon descent

Clinical Findings

Signs and Symptoms

  • Bone growth

  • Bone pain

  • Bone deformity

  • Enlarged head

  • Hearing loss

  • Headaches

  • Joint pain

  • Tingling

  • Muscle weakness

  • Nerve compression

  • Joint stiffness

  • Genu varus

  • Neck pain

  • Pathologic fractures

  • Osteoarthritis

  • Heart failure

  • Bone cancer

Functional Implications

  • Delayed fracture union

  • Hearing problems

  • Gait dysfunction

Possible Contributing Causes

  • Age (>/= 50 years)

  • Gender (female>male)

  • No specific cause

  • Several genes maybe related

  • Hereditary

  • Insufficient calcium and vitamin D

Differential Diagnoses

  • Trauma

  • Pathologic fracture from neoplasm

  • Osteogenesis imperfecta

  • Inadequate mineralization of existing bone matrix (osteoid) or poor bone quality

  • Osteoporosis

  • Infections, such as tuberculosis

  • Fibrous dysplasia

  • Peripheral neuropathy

  • Repetitive stress fractures

  • Multiple myeloma, lymphoma, or metastatic cancer

  • Leukemia

  • Renal osteodystrophy

  • Hormone deficiency (estrogen in women; androgen in men)

  • Cushing's syndrome or glucocorticoid administration

  • Hyperthyroidism

  • Hyperparathyroidism

  • History of drug abuse or misuse (alcohol, tobacco)

  • Excessive vitamin D and A

  • Juvenile osteoporosis occurs in children or young adults of both genders with normal gonadal function; onset typically occurs around age 8 to 14 years and hallmarks include rapid onset of bone pain and/or fracture secondary to trauma

  • Type I (Postmenopausal osteoporosis) typically occurs in women 50 to 65 years of age and is characterized by accelerated bone loss (trabecular bone)

  • Type II (Age-associated or senile osteoporosis) presents in women and men older than 70 years of age as a result of bone loss associated with the aging process; fractures occur in both cortical and trabecular bone

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