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CHAPTER 8: Basal Nuclei

Injury to which of the basal nuclei is associated with Huntington's disease?

A. The striatum

B. The subthalamic nucleus

C. The substantia nigra pars compacta

D. The globus pallidus internus

A. The striatum

The most well-known and best-studied basal nuclei circuit is the:

A. associative loop.

B. motor loop.

C. visual loop.

D. limbic loop.

B. motor loop.

Developmentally, which nuclei are most closely related?

A. The substantia nigra pars compacta and the globus pallidus externa

B. The putamen and the subthalamic nucleus

C. The substantia nigra pars reticularis and the globus pallidus interna

D. The caudate and the subthalamic nucleus

C. The substantia nigra pars reticularis and the globus pallidus interna

Output from the subthalamic nucleus:

A. is inhibitory to the globus pallidus externa.

B. is excitatory to the striatum.

C. is inhibitory to the thalamus.

D. is excitatory to the globus pallidus interna.

D. is excitatory to the globus pallidus interna.

Loss of which neurotransmitter is associated with Parkinson's disease?

A. Serotonin

B. Glutamate

C. Dopamine

D. GABA

C. Dopamine

Lesions in the basal nuclei:

A. produce tremors on intention.

B. produce contralateral deficits.

C. produce only motor deficits.

D. produce ataxia, tremor, and nystagmus.

B. produce contralateral deficits.

Which of the following statements concerning the direct and indirect basal nuclei pathways is correct?

A. The indirect pathway reduces movement and “selects” meaningful motor activity.

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