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Chapter 2: Pharmacodynamics

Which of the following would bind mainly to the inactive form of the receptor and decrease the constitutive activity of the receptor-mediated system?

a. Inverse agonist

b. Full agonist

c. Partial agonist

d. Neutral antagonist

Four drugs bind to the same receptor. The drug and dose for each drug that produces a 50% maximal response is listed below. Which drug has the greatest potency?

a. Drug A 5 mcg/kg

b. Drug B 2 mcg/kg

c. Drug C 6 mcg/kg

d. Drug D 3 mcg/kg

Which of the following formulas represents the therapeutic index?

a. TD50 divided by the LD50

b. LD50 divided by the TD50

c. TD50 divided by the ED50

d. ED50 divided by the LD50

Which of the therapeutic indices below represents the safest drug based on the therapeutic index?

a. 5

b. 0

c. −3

d. 8

Drug A is a full agonist at a receptor. When drug B is added, the maximal response to drug A is decreased, but there is minimal change in the dosage of drug A required to generate a 50% maximal response. Drug B binds at a different site at the same receptor for drug A. Which of the following is drug B?

a. Allosteric inhibitor

b. Partial agonist

c. Competitive antagonist

d. Irreversible antagonist

A drug binds to a receptor, causing the intracellular formation of cyclic adenosine monophosphate (cAMP) by the enzyme adenylate cyclase. This system is which of the following?

a. Intracellular receptor

b. G protein-coupled receptor

c. Tyrosine kinase–mediated receptor

d. Ligand-gated ion channel receptor

Which of the following ...

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