Chapter 9: Drugs Used in Heart Failure

Chapter 9: Drugs Used in Heart Failure

A decrease in ejection fraction due to decreased myocardial fiber contraction characterizes which of the following?

a. Systolic heart failure

b. Diastolic heart failure

c. Combined systolic/diastolic heart failure

d. High output heart failure

Which of the following drugs increases cardiac contractility by inhibiting the Na⁺/K⁺/ATPase?

a. Dopamine

b. Dobutamine

c. Digoxin

d. Sacubitril

Which of the following drugs may exacerbate the pharmacologic effects of digoxin and increase the risk of an adverse effect?

a. Captopril

b. Furosemide

c. Metoprolol

d. Spironolactone

Which of the following drugs increases cardiac contractility by acting as an agonist at cardiac β receptors?

a. Captopril

b. Digoxin

c. Dobutamine

d. Hydrochlorothiazide

Which of the following drugs increases cardiac contractility by increasing intracellular cyclic adenosine monophosphate (cAMP) by inhibiting phosphodiesterase?

a. Labetalol

b. Digoxin

c. Dobutamine

d. Milrinone

Which of the following drugs is combined with sacubitril to minimize the adverse effects of inhibiting neprilysin?

a. Furosemide

b. Propranolol

c. Captopril

d. Valsartan

Which of the following drugs acts only by inhibiting vasopressin 2 (V₂) receptors in the kidney?

a. Vasopressin

b. Conivaptan

c. Tolvaptan

d. Antidiuretic hormone

With respect to its use in heart failure, dopamine would be considered which of the following?

a. ADH antagonist

b. Neurotransmitter