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Chapter 12: Introduction to the Pharmacology of Central Nervous System Drugs

Which of the following neurotransmitters does not act primarily as an inhibitory neurotransmitter?

a. Glutamate

b. Glycine

c. Dopamine

d. GABA

Which of the following actions would result from activation of metabotropic receptors?

a. Direct opening of an ion channel

b. Direct closing of an ion channel

c. Activation of a G protein that can modulate an ion channel

d. Fast IPSPs in the brain

Which of the following neurotransmitters is not a monoamine and therefore will not be susceptible to breakdown by monoamine oxidase?

a. Dopamine

b. Norepinephrine

c. Acetylcholine

d. Serotonin

Which of the following chemicals does not meet criteria for a neurotransmitter?

a. Dopamine

b. Acetylcholine

c. Glycine

d. Cyclic AMP

In the central nervous system, which of the following chemicals is co-released with a traditional neurotransmitter?

a. Histamine

b. Substance P

c. Glutamate

d. Dopamine

Which of the following receptors activates the same family of potassium channels as the 5-HT1A receptors?

a. GABAB receptors

b. Dopamine D1 receptors

c. Muscarinic M1 receptors

d. Noradrenergic α1 receptors

Which of the following is a property of hierarchical neuronal systems?

a. Release of neuropeptides

b. Axons with wide and diffuse projections throughout the brain

c. Actions primarily mediated by glutamate and GABA in the brain

d. Actions primarily mediated by metabotropic receptors

Retrograde synaptic signaling has been demonstrated ...

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