Chapter 14: Antiseizure Drugs

Chapter 14: Antiseizure Drugs

Which of the following is not a mechanism of action for drugs with antiseizure activity?

a. Positive modulation of GABA_A receptors

b. GABA_A receptor antagonism

c. Blockade of glutamatergic AMPA receptors

d. Inhibition of voltage-gated sodium channels

Which of the following statements is true regarding the pharmacological treatment of seizures?

a. In some people, simultaneous use of multiple drugs may be necessary to provide adequate seizure control.

b. Since most seizures are self-limiting, drugs are only used when an individual has a seizure that lasts more than 5 minutes.

c. In those with epilepsy, antiseizure drugs are typically only taken for a short time after the occurrence of a seizure.

d. Once an individual starts taking an antiseizure medication, continuous use must occur for the person’s lifetime.

Which of the following drugs does not have its antiseizure effect by blocking sodium channels?

a. Phenytoin

b. Carbamazepine

c. Lamotrigine

d. Levetiracetam

Which of the following antiseizure drugs does not tend to have a sedative effect at usual therapeutic doses?

a. Tiagabine

b. Phenobarbital

c. Carbamazepine

d. Levetiracetam

Use of which of the following antiseizure drugs has been associated with cognitive slowing, particularly in the verbal realm?

a. Gabapentin

b. Topiramate

c. Valproic acid

d. Carbamazepine

Which of the following statements is true regarding the use of benzodiazepines in the treatment of seizures?

a. Certain benzodiazepines are first-line agents to treat generalized onset seizures.

b. Certain benzodiazepines are first-line agents to treat focal onset seizures.

c. Certain benzodiazepines are first-line agents to treat generalized absence seizures.

d. Certain benzodiazepines are first-line agents to treat status epilepticus.

Which ...