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Chapter 18: Antipsychotic Agents and Lithium

Which of the following drugs is most associated with tardive dyskinesia as an adverse effect?

a. Haloperidol

b. Lithium

c. Aripiprazole

d. Valproic acid

Which of the following antipsychotic drugs has the most sedative action?

a. Haloperidol

b. Chlorpromazine

c. Olanzapine

d. Aripiprazole

Inhibition of which of the following receptors is most closely associated with Parkinson’s-like adverse effects?

a. Muscarinic receptors

b. Serotonin 5-HT2 receptors

c. Dopamine D2 receptors

d. Glutamate receptors

The newer “second generation” antipsychotic drugs have a greater affinity for which of the following receptors as a hypothesized mechanism of action?

a. Dopamine D1 receptors

b. Glutamate receptors

c. Histamine H1 receptors

d. Serotonin 5-HT2 receptors

Why was pimavanserin specifically developed to treat psychosis associated with Parkinson’s disease?

a. The drug has no dopamine receptor antagonism.

b. The drug has no serotonin receptor antagonism.

c. The drug has muscarinic receptor antagonism.

d. The drug has no glutamate receptor antagonism.

Blockade of which of the following receptors by antipsychotic drugs would most likely be associated with orthostatic hypotension?

a. Muscarinic receptors

b. Adrenergic α1 receptors

c. Dopamine D2 receptors

d. Serotonin 5-HT1 receptors

Which of the following is not considered a mechanism associated with the clinical effect of lithium?

a. Inhibition of intracellular second messenger diacylglycerol

b. Inhibition of intracellular second messenger inositol triphosphate

c. Substitution for potassium in membrane action potentials

d. Inhibition of glycogen synthase kinase-3

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