Chapter 23: Corticosteroids and Corticosteroid Antagonists

Chapter 23: Corticosteroids and Corticosteroid Antagonists

Which of the following is not an adverse effect of prolonged systemic glucocorticoid use?

a. Vertebral fractures

b. Hypoglycemia

c. Proximal muscle wasting

d. Immunosuppression

Which mechanism is partly responsible for the anti-inflammatory actions of glucocorticoids?

a. Increased production of arachidonic acid

b. Increased production of interleukin-1

c. Increased release of lymphocytes in circulation

d. Inhibition of white blood cell migration from circulation to affected tissue

Individuals with chronic adrenal cortical insufficiency (Addison’s disease) must receive exogenous glucocorticoids to survive.

a. True

b. False

Which of the following is not true regarding adrenal suppression that occurs as a result of chronic systemic glucocorticoid use?

a. Exogenous glucocorticoids must be discontinued when patients have a serious illness.

b. Adrenal suppression can occur when exogenous glucocorticoids are given for less than a month.

c. Higher doses of exogenous glucocorticoids are given when patients have a major surgery.

d. Individuals who have taken glucocorticoids for a long time have their doses tapered gradually to allow recovery of adrenal function.

Which of the following adverse drug reactions might be expected even after short-duration systemic glucocorticoid use?

a. Moon face

b. Behavioral changes

c. Buffalo hump

d. Muscle wasting

Which strategy is not used to decrease the toxicity of glucocorticoids?

a. Alternate-day therapy

b. Dose tapering soon after therapeutic response

c. High oral doses for long durations

d. Local administration

Which of the following conditions is likely to worsen with glucocorticoid injections?

a. Bursitis

b. Arthritis

c. Tenosynovitis

d. Lateral epicondylalgia