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Chapter 27: Antibacterial Agents

Which of the following drugs may be used to treat infections caused by methicillin-resistant staphylococcus (MRSA)?

a. Cefazolin

b. Vancomycin

c. Penicillin G

d. Nafcillin

Which of the following is not a recognized mechanism of bacterial resistance to antibiotics?

a. Production of β-lactam rings

b. Production of β-lactamases

c. Modifications in target penicillin binding proteins

d. Decreased cell wall permeability to antibiotics

Which of the following statements is true regarding the cephalosporins?

a. The bactericidal effects of cephalosporins result from inhibition of bacterial protein synthesis.

b. Cephalosporins are classified by generation according to their spectrum of activity.

c. The cephalosporins can only be administered parenterally.

d. Some individuals with a history of penicillin allergy may be treated successfully with a cephalosporin.

Which of the following drug classes does not have its antibacterial effect by inhibiting the synthesis of bacterial cell walls?

a. Cephalosporins

b. Penicillins

c. Aminoglycosides

d. Carbapenems

Which of the following antibiotic classes is associated with significant ototoxicity?

a. Penicillins

b. Aminoglycosides

c. Tetracyclines

d. Cephalosporins

Tendonitis and neuropathy are potential adverse reactions for which of the following drug classes?

a. Tetracyclines

b. Cephalosporins

c. Carbapenems

d. Fluoroquinolones

Which of the following statements is true?

a. Chemotherapy for mycobacterial infections requires multidrug regimens over long periods (ie, months).

b. Leprosy is the most common mycobacterial infection in the United States.

c. Mycobacteria rarely develop resistance to treatment when an individual drug is used as monotherapy.

d. Drugs that ...

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