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Chapter 31: Cancer Chemotherapy

Which of the following statements regarding the log-kill hypothesis is true?

a. A 2-log-kill dose represents a decrease in tumor cells from 1000 cells to 10 cells.

b. A 2-log-kill dose represents a decrease in tumor cells from 1000 to 500 cells.

c. A 2-log-kill dose represents a decrease in tumor cells from 1012 to 108.

d. The log-kill hypothesis is most applicable to the treatment of human solid tumors.

Which of the following refers to adjuvant chemotherapy?

a. The use of chemotherapy as the main cancer treatment

b. The use of chemotherapy after local methods of cancer treatment

c. The use of chemotherapy in people who present with cancer for which local cancer treatment has not been completely effective

d. The use of only one cytotoxic drug

Which of the following anticancer drugs does not have its effect by alkylation?

a. Bleomycin

b. Cyclophosphamide

c. Carboplatin

d. Procarbazine

Which of the following statements is true regarding antimetabolite chemotherapy agents?

a. Antimetabolites are CCNS agents.

b. Methotrexate is a classic antimetabolite that acts by inhibiting an enzyme required for cell proliferation and growth.

c. Antimetabolites are CCS drugs that act primarily in the M phase of the cell cycle.

d. The toxicities associated with antimetabolites can be avoided with adequate hydration.

Which of the following drugs would not be considered a plant-derived anticancer agent?

a. Topotecan

b. Vinblastine

c. Vincristine

d. 5-fluorouracil

Which of the following statements is true regarding the anthracyclines?

a. Gastrointestinal distress is the primary dose-limiting toxicity of the anthracyclines.

b. The only cardiac toxicity associated with the anthracyclines is transient arrhythmias.

c. Anthracyclines are a class of antibiotics that must be given intravenously.

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