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Chapter 32: Immunopharmacology

Which of the following drugs binds to FK506-binding protein and inhibits the molecular target of rapamycin?

a. Sirolimus

b. Tacrolimus

c. Cyclosporine

d. Azathioprine

Which of the following drug’s immunosuppressant action results from increasing extracellular adenosine levels?

a. Everolimus

b. Pentostatin

c. Teriflunomide

d. Thalidomide

Which of the following monoclonal antibodies is an immune enhancer that binds to CTLA-4 receptor on T cells?

a. Atezolizumab

b. Nivolumab

c. Ipilimumab

d. Antithymocyte globulin

Which of the following drugs is a monoclonal antibody that may cause progressive multifocal leukoencephalopathy?

a. Glatiramer acetate

b. Basiliximab

c. Alemtuzumab

d. Natalizumab

Which of the following hypersensitivity responses is mediated by IgE?

a. Type 1 hypersensitivity

b. Type 3 hypersensitivity

c. Type 4 hypersensitivity

d. Type 2 hypersensitivity

Which of the following hypersensitivity responses is mediated by T cells?

a. Type I hypersensitivity

b. Type IV hypersensitivity

c. Type III hypersensitivity

d. Type II hypersensitivity

Which of the following drugs has been associated with the adverse effect of inhibition of limb bud development in utero?

a. Mycophenolate mofetil

b. Dimethyl fumarate

c. Thalidomide

d. Hydroxychloroquine

Which of the following cell types is responsible for antibody production in the immune response?

a. T cells

b. NK cells

c. Macrophages

d. B cells

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