Minimal change glomerular disease
|
Nephrotic syndrome
|
−
|
−
|
−
|
−
|
−
|
−
|
Foot process fusion
|
Diffuse
|
?T–cell mediated (lymphokines)
|
Proliferative glomerulonephritis
|
Poststreptococcal glomerulonephritis
|
Acute nephritic syndrome, nephrotic syndrome
|
+ Crescents (occasionally)
|
−
|
Granular
| IgG |
+
|
−
|
Subepithelial humps
|
Diffuse
|
Immune complex
|
Crescentic glomerulonephritis
|
Acute nephritic syndrome, rapidly progressive
|
+ Crescents
|
−
|
Granular, linear, or pauci–immune
|
IgG/IgA
|
+
|
+
|
Variable deposits
|
Diffuse
|
Immune complex or basement membrane antibody
|
Anti–basement membrane disease (Goodpasture's syndrome)
|
Acute nephritic syndrome
|
+ Crescents
|
±
|
Linear
| IgG |
+
|
+
|
Thick basement membrane
|
Focal → diffuse
|
Basement membrane antibody (also lung)
|
Mesangioproliferative glomerulonephritis IgG |
Proteinuria, hematuria
|
+ Mesangial
|
−
|
Mesangial
| IgG |
+
|
−
|
Mesangial deposits
|
Diffuse
|
Immune complex
|
IgA (Berger's disease)
|
Nephrotic syndrome, proteinuria, hematuria, acute nephritic syndrome
|
IgA
|
+
|
−
|
IgA (Henoch–Schönlein purpura)
|
Nephrotic syndrome, proteinuria, hematuria, acute nephritic syndrome
|
IgA
|
+
|
+
|
Membranous glomerulonephritis
|
Proteinuria, nephrotic syndrome, chronic renal failure
|
−
|
+
|
Granular
| IgG |
±
|
−
|
Subepithelial deposits, spikes, split basement membrane
|
Diffuse
|
Immune complex; probably formed in situ
|
Membranoproliferative glomerulonephritis (mesangiocapillary) I
|
Acute nephritic, syndrome, nephrotic syndrome
|
+ Endothelial, mesangial
|
+
|
Granular
| IgG |
+
|
−
|
Subendothelial deposits, split basement membrane
|
Diffuse
|
Immune complex
|
II
|
Nephrotic syndrome, chronic renal failure
|
Granular
|
−
|
+
|
−
|
Thick basement membrane, dense deposits
|
Diffuse
|
Immune complex; probably alternative pathway
|
Focal glomerulonephritis
|
Proteinuria, nephrotic syndrome
|
+ Focal
|
±
|
Granular
|
IgM, IgA
|
+
|
+
|
Foot process fusion
|
Focal plus segmental
|
?Immune complex
|
Secondary glomerulonephritis, systemic lupus erythematosus, polyarteritis nodosa, etc
|
Variable
|
Variable +
|
Variable + (wireloops in systemic lupus erythematosus)
|
Granular
| IgG |
+
|
+
|
Variable
|
Diffuse/focal
|
Immune complex
|
Chronic glomerulonephritis
|
Chronic renal failure
|
Any of above
|
Granular, linear: variable
|
Variable
|
Diffuse
|
Immune complex/antibasement membrane antibody
|
Diabetic nephropathy
|
Nephrotic syndrome, chronic renal failure
|
−
|
Focal sclerosis
|
None
|
−
|
−
|
−
|
Sclerosis
|
Diffuse/focal
|
Unknown
|
Amyloidosis
|
Nephrotic syndrome, chronic renal failure
|
−
|
+
|
None
|
−
|
−
|
−
|
Fibrillar amyloid
|
Diffuse
|
Deposition of amyloid protein
|