Appendix D. Analgesic and Nonsteroidal Anti-Inflammatory Drugs

Non-Steroidal Anti-Inflammatory Drugs

Diclofenac sodium

Voltaren®

100–200 mg daily

2–3 mg/kg/d

(2–4 divided doses)

(2–4 divided doses)

*ER given 1–2 × daily*

Diclofenac potassium

Cataflam®

100–200 mg daily

2–3 mg/kg/d

(2–4 divided doses)

(2–4 divided doses)

Diclofenac epolamine

Flector®

180 mg patch every 12 hr

N/A

Etodolac

600–1000 mg daily

20–30 kg: 400 mg daily

(2–3 divided doses)

31–45 kg: 600 mg daily

46–60kg: 800 mg daily

>60 kg: 1000 mg daily

*Age 6–16 y*

*Based on ER product*

Fenoprofen calcium

Nalfon®

200–600 mg 3–4 x/d

N/A

Max 3200 mg/d

Flurbiprofen

Ansaid®

200–300 mg daily

N/A

(2–4 divided doses)

Ibuprofen

Motrin®

1200–3200 mg daily

4–10 mg/kg/dose 3–4×/d

(3–4 divided doses)

Max 40 mg/kg/d

Indomethacin

Indocin®

50–200 mg daily

1–2 mg/kg/d

(2–3 divided doses)

(2–4 divided doses)

Max 4 mg/kg/d, NTE: 150–200 mg/d

*Age >2 y*

Ketoprofen

IR: 150–300 mg daily

N/A

(3–4 divided doses)

ER: 100–200 mg daily

Ketorolac tromethamine

Toradol®

20 mg initially, 10 mg 4x/d

N/A

Max 5-d duration

Meclofenamate sodium

200–400 mg daily

N/A

(3–4 divided doses)

Mefenamic acid

Ponstel®

500 mg initially, 250 mg every 6 h as needed (NTE: 1 wk)

N/A

Meloxicam

Mobic®

7.5–15 mg daily

0.125 mg/kg/d

Max 7.5 mg daily

*Age ≥2 y*

Nabumetone

500–2000 mg daily

N/A

(1–2 divided doses)

Naproxen

Naproxen sodium: Anaprox®, Anaprox DS®, Aleve® (OTC)

Naproxen: 250–500 mg 2×/d

*Analgesia: 5–7 mg/kg/dose every 8–12 h

Naproxen sodium: 200–500 mg 2×/d

*Inflammatory disease: 10–15 mg/kg/d (2 divided doses)

Naproxen DR: 375–500 mg 2×/d

Max 1000 mg/d

Naproxen: Naprosyn®

*Age >2 y*

Oxaprozin

Daypro®

600–1200 mg daily Max 1800 mg daily (in divided doses)

22–31 kg: 600 mg daily

32–54 kg: 900 mg daily

≥55 kg: 1200 mg daily

*Age 6–16 y*

Piroxicam

Feldene®

10–20 mg daily

0.2–0.3 mg/kg/d

Max 15 mg daily

Sulindac

Clinoril®

150–200 mg 2×/d

2–4 mg/kg/d

(2 divided doses)

Max 6 mg/kg/d, NTE: 400 mg/d

Tolmetin sodium

600–1800 mg daily

*Analagesia: 5–7 mg/kg/dose every 6–8 h

(3 divided doses)

Max 2000 mg daily

*Inflammatory disease: 15–30 mg/kg/d (3–4 divided doses)

NTE: 1800 mg/d

*Age ≥2 y*

Celecoxib

Celebrex®

100–400 mg daily

10–25 kg: 50 mg 2×/d

(1–2 divided doses)

>25 kg: 100 mg 2×/d

*Age ≥2 y*

Salicylates

Diflunisal

500–1000 mg daily

N/A

(2–3 divided doses)

Max 1500 mg daily

Magnesium salicylate

Novosal®, Doan's Extra Strength®

Novosal®: 600 mg 3–4× d, Max 4800 mg daily

N/A

Doan's®: 934 mg every 6h as needed

Salsalate

Amigesic®, Salflex®

3000 mg daily

N/A

(2–4 divided doses)

Choline magnesium trisalicylate

500–1500 mg 2–3×/d

30–60 mg/kg/d

(3–4 divided doses)