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  • 279.06 Common variable immunodeficiency
  • 279.2 Combined immunity deficiency

  • 315.4 Developmental coordination disorder
  • 718.45 Contracture of joint, pelvic region, and thigh
  • 719.70 Difficulty in walking involving joint site unspecified
  • 728.2 Muscular wasting and disuse atrophy, not elsewhere classified
  • 728.89 Other disorders of muscle, ligament, and fascia
  • 729.9 Other and unspecified disorders of soft tissue
  • 780.7 Malaise and fatigue
  • 781.2 Abnormality of gait
  • 782.3 Edema
  • 786.0 Dyspnea and respiratory abnormalities
  • 786.05 Shortness of breath

  • D83.8 Other common variable immunodeficiencies
  • D83.9 Common variable immunodeficiency, unspecified
  • D81.0 Severe combined immunodeficiency (SCID) with reticular dysgenesis
  • D81.1 Severe combined immunodeficiency (SCID) with low T- and B-cell numbers
  • D81.2 Severe combined immunodeficiency (SCID) with low or normal B-cell numbers
  • D81.89 Other combined immunodeficiencies
  • D81.9 Combined immunodeficiency, unspecified


  • Failure of the body to provide defense against bacterial or viral invasion as there is no or insufficient production of antibodies
  • There are 70 to 100 types in approximately six categories
  • Primary immunodeficiency disorders
  • Congenital immunodeficiency diseases
  • B-cell (antibody) deficiencies
  • T-cell deficiencies
  • Combination B- and T-cell deficiencies
  • Defective phagocytes
  • Complement deficiencies
  • Unknown (idiopathic)
  • Severe combined immunodeficiency (SCID) (bubble boy disease) is considered the most severe form of the disease
    • Chronic infections
    • Frequent infections
    • Multiple body-system involvement
    • Onset often vague with misdiagnosis of underlying disease

Essentials of Diagnosis

  • Must be made by a physician and confirmed by medical diagnostic testing
  • Warning signs of primary immunodeficiency
    • Eight or more new ear infections within one year
    • Two or more serious sinus infections within one year
    • Two or more months on antibiotics with little effect
    • Two or more pneumonias within one year
    • Failure of an infant to gain weight or grow normally
    • Recurrent, deep skin or organ abscesses
    • Persistent thrush in mouth or elsewhere on skin, after age one
    • Need for intravenous antibiotics to clear infections
    • Two or more deep-seated infections such as sepsis, meningitis, or cellulitis
    • A family history of primary immune deficiency
  • Frequent/recurrent Infections
  • Blood infections
  • Inflammation of internal organs: liver, spleen, pancreas
  • Autoimmune disorders
  • Blood disorders
  • Digestive problems
  • Delayed growth and development
  • Genetic factors
  • Abscessed wounds
  • Ineffective use of antibiotics

General Considerations

  • May result in secondary problems such as aerobic capacity and muscle endurance impairment, sarcopenia, weakness/impaired muscle performance, musculoskeletal problems, neuromuscular problems, weight loss indicating the need for PT intervention depending on severity
  • Once thought ...

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