Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ CONDITION/DISORDER SYNONYM ++ Severe combined immunodeficiency (SCID) +++ ICD-9-CM CODES ++ 279.06 Common variable immunodeficiency 279.2 Combined immunity deficiency Associated ICD-9-CM PT diagnoses/treatment diagnosis that may be directly related 315.4 Developmental coordination disorder 718.45 Contracture of joint, pelvic region and thigh 719.70 Difficulty in walking involving joint site unspecified 728.2 Muscular wasting and disuse atrophy, not elsewhere classified 728.89 Other disorders of muscle, ligament, and fascia 729.9 Other and unspecified disorders of soft tissue 780.7 Malaise and fatigue 781.2 Abnormality of gait 782.3 Edema 786.0 Dyspnea and respiratory abnormalities 786.05 Shortness of breath +++ ICD-10-CM CODES ++ D81.0 Severe combined immunodeficiency (SCID) with reticular dysgenesis D81.1 Severe combined immunodeficiency (SCID) with low T- and B-cell numbers D81.2 Severe combined immunodeficiency (SCID) with low or normal B-cell numbers D81.89 Other combined immunodeficiencies D81.9 Combined immunodeficiency, unspecified D83.8 Other common variable immunodeficiencies D83.9 Common variable immunodeficiency, unspecified ++ FIGURE 48-1 T cell differentiation, effector pathways, and related primary immunodeficiencies (PIDs). Hematopoietic stem cells (HSCs) differentiate into common lymphoid progenitors (CLPs), which, in turn, give rise to the T cell precursors that migrate to the thymus. The development of CD4+ and CD8+ T cells is shown. Known T cell effector pathways are indicated, that is, γδ cells, cytotoxic T cells (Tc), TH1, TH2, TH17, TFh (follicular helper) CD4 effector T cells, regulatory T cells (Treg), and natural killer T cells (NKTs); abbreviations for PIDs are contained in boxes. Vertical bars indicate a complete deficiency; broken bars a partial deficiency. SCID, severe combined immunodeficiency; ZAP 70, zeta-associated protein deficiency, MHCII, major histocompatibility complex class II deficiency; TAP, TAP1 and 2 deficiencies; Orai1, Stim1 deficiencies; HLH, hematopoietic lymphohistiocytosis; MSMD, Mendelian susceptibility to mycobacterial disease; Tyk2, DOCK8, autosomal recessive form of hyper-IgE syndrome; STAT3, autosomal dominant form of hyper-IgE syndrome; CD40L, ICOS, SAP deficiencies; IPEX, immunodysregulation polyendocrinopathy enteropathy X-linked syndrome; XLP, X-linked proliferative syndromes. (From Longo DL, Fauci AS, Kasper DL, Hauser SL, JamesonJL, Loscalzo J, eds. Harrison’s Principles of Internal Medicine. 18th ed. New York, NY: McGraw-Hill; 2012.) Graphic Jump LocationView Full Size||Download Slide (.ppt) ++ FIGURE 48-2 General approach to primary immunodeficiencies. (From Hay WM, et al. Current Diagnosis & Treatment: Pediatrics, 21st ed. New York, NY: McGraw-Hill. www.accessmedicine.com. Copyright © The McGraw-Hill Companies, Inc. All rights reserved.) Graphic Jump LocationView Full Size||Download Slide (.ppt) +++ PREFERRED PRACTICE PATTERNS1 ++ Note: The APTA Guide to Physical Therapist Practice includes practice patterns for neuromuscular and musculoskeletal systems; as primary immunodeficiency is medical in nature, the practice patterns addressed are those for associated disorders that may occur and impair aerobic capacity. 4D: Impaired Joint Mobility, Motor Function, Muscle Performance, and Range of Motion Associated with Connective Tissue Dysfunction 4E: Impaired Joint Mobility, Motor Function, Muscle Performance, and Range of Motion Associated with Localized Inflammation 6B: Impaired Aerobic ... Your Access profile is currently affiliated with [InstitutionA] and is in the process of switching affiliations to [InstitutionB]. Please select how you would like to proceed. Keep the current affiliation with [InstitutionA] and continue with the Access profile sign in process Switch affiliation to [InstitutionB] and continue with the Access profile sign in process Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Error: Incorrect UserName or Password Username Error: Please enter User Name Password Error: Please enter Password Sign in Forgot Password? Forgot Username? Sign in via OpenAthens Sign in via Shibboleth You already have access! Please proceed to your institution's subscription. Create a free profile for additional features.