TY - CHAP M1 - Book, Section TI - Chapter 25. Drugs That Affect Bone Mineral Homeostasis A1 - Panus, Peter C. A1 - Jobst, Erin E. A1 - Masters, Susan B. A1 - Katzung, Bertram A1 - Tinsley, Suzanne L. A1 - Trevor, Anthony J. PY - 2009 T2 - Pharmacology for the Physical Therapist AB - Calcium and phosphate are the major mineral constituents of bone and are also two of the most important minerals for general cellular function. Accordingly, the body has evolved a complex set of mechanisms by which calcium and phosphate homeostasis is carefully maintained. Approximately 98% of the 1 to 2 kg of calcium and 85% of the 1 kg of phosphorus in the human adult are found in bone, the principal reservoir for these minerals. Mineral homeostasis is dynamic, with constant remodeling of bone and ready exchange of bone minerals with free ions in the extracellular fluid. Bone also serves as the principal structural support for the body and provides space for hematopoiesis in the bone marrow. Abnormalities in bone mineral homeostasis can underlie electrolyte disturbances, resulting in the clinical manifestations of muscle weakness, tetany, and coma. Dysfunction in bone mineral homeostasis can also disturb the structural support of the body in the form of osteoporosis and fractures. Hematopoietic capacity may also be reduced in conditions such as infantile osteopetrosis. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessphysiotherapy.mhmedical.com/content.aspx?aid=6093731 ER -