TY - CHAP M1 - Book, Section TI - Chapter 38. Pathophysiology of Myoclonic Disorders A1 - Toro, Camilo A1 - Hallett, Mark A2 - Watts, Ray L. A2 - Standaert, David G. A2 - Obeso, Jose A. PY - 2012 T2 - Movement Disorders, 3e AB - The electrophysiological study of myoclonic movements touches on the interests of clinical electrophysiologists, epileptologists, movement disorders specialists, and sleep medicine specialists alike. As early as 1935, Gibbs and colleagues1 had described patients with spike-and-wave discharges in the electroencephalogram (EEG), with muscle jerking at the same rate as the EEG spikes. Grinker and colleagues2 are credited with the first description of polyspike discharges in the EEG, with close association to myoclonic jerking in patients with progressive myoclonic epilepsy. In 1946, Dawson3 produced a detailed description of the relationship between EEG spikes and muscle jerks in patients with myoclonus, reporting also, in some of his patients, the possibility of inducing myoclonic jerks by tendon tapping. One year later, Dawson himself demonstrated not only the first recording of somatosensory-evoked potentials (SEPs) from the scalp in humans,4 but also that the SEPs in patients with myoclonus could be grossly exaggerated in amplitude.5 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/10/07 UR - accessphysiotherapy.mhmedical.com/content.aspx?aid=55802229 ER -