TY - CHAP M1 - Book, Section TI - Opioid Analgesics and Antagonists A1 - Jobst, Erin E. A1 - Panus, Peter C. A1 - Kruidering-Hall, Marieke Y1 - 2020 N1 - T2 - Pharmacology for the Physical Therapist, 2e AB - CASE STUDYS.F. is a 58-year-old woman with a long history of bilateral knee osteoarthritis. For the past several years, conservative treatment has included physical therapy and medications (oral cyclooxygenase-2 [COX-2] inhibitors and intra-articular triamcinolone acetonide injections). Because she has had progressively more pain and dysfunction over the past year, S.F. and her primary physician determined that it was time for bilateral total knee arthroplasties (TKA). The patient subsequently underwent bilateral TKA without complication. Postsurgical inpatient pain management includes oral oxycodone and a PCA pump with morphine sulfate for breakthrough pain. Early physical therapy interventions on postoperative days 1 and 2 focused on active and passive range of motion (ROM) of both lower extremities, transfer training, and upright mobility training. Prior to surgery, S.F. stated that her goal was to discharge from the hospital directly to her home. Her strong preference is not to be admitted to a skilled nursing facility, even for a short time. In line with this goal, S.F. has eagerly and actively participated in twice-daily physical therapy sessions. She has informed the nursing staff that she has a low tolerance for pain and asks for the oral pain medication 30-45 minutes before each therapy session. Initially, S.F. tolerated ROM exercises and limited mobility training well with this “pain premedication” regimen. However, upon standing and attempting gait training on postoperative day three, S.F. experienced dizziness, diaphoresis, and became very short of breath. On the second attempt to stand, the patient experienced syncope. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/23 UR - accessphysiotherapy.mhmedical.com/content.aspx?aid=1192816551 ER -