TY - CHAP M1 - Book, Section TI - Chapter 17. Stereotaxic Surgery and Deep Brain Stimulation for Parkinson's Disease and Movement Disorders A1 - Deogonkar, Milind A1 - Machado, Andre A1 - Vitek, Jerrold L. A2 - Watts, Ray L. A2 - Standaert, David G. A2 - Obeso, Jose A. Y1 - 2012 N1 - T2 - Movement Disorders, 3e AB - Functional surgery for movement disorders can significantly alleviate the motor symptoms associated with these disorders and improve the quality of life for patients with disabling diseases such as Parkinson's disease (PD), essential tremor (ET), and dystonia in appropriately selected patients. The surgical approach to movement disorders has evolved dramatically from the pre-L-dopa era to the development of modern magnetic resonance imaging (MRI)-based stereotaxic and neurophysiologic guided targeting. Current stereotactic approaches have benefited from the concurrent growth in our understanding of the functional organization of target structures and the pathophysiological basis underlying the development of these disorders. The resurgence of ablative therapy in the 1990s has given way to the development of chronic electrical stimulation of deep brain structures, that is, deep brain stimulation (DBS). DBS has given us the ability to explore surgical therapies for neurological disorders not previously approachable through ablative therapy, given the reversibility of side effects and the ability to modify stimulation parameters to optimize results. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessphysiotherapy.mhmedical.com/content.aspx?aid=55794986 ER -