TY - CHAP M1 - Book, Section TI - Chapter 19. Parkinson's Disease: Neuropathology A1 - Duda, John E. A2 - Watts, Ray L. A2 - Standaert, David G. A2 - Obeso, Jose A. Y1 - 2012 N1 - T2 - Movement Disorders, 3e AB - From the recognition of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism to the discovery of numerous genes responsible for rare Mendelian forms of parkinsonism, our understanding of the mechanisms involved in rare causes of parkinsonism has exploded in the past 25 years. It was hoped that further understanding of the pathophysiologic mechanisms involved in these conditions would lead to novel therapeutic interventions for people afflicted with what is by far the most common form of parkinsonism, Lewy body Parkinson's disease (hereafter referred to as PD). As clues to the pathophysiology of these other forms of parkinsonism arose, cellular and animal models designed to recapitulate these mechanisms were developed. These models have enhanced our understanding of nigrostriatal degeneration and basal ganglionic circuitry. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessphysiotherapy.mhmedical.com/content.aspx?aid=55795913 ER -