TY - CHAP M1 - Book, Section TI - Chapter 67. Diseases of Bones A1 - Chandrasoma, Parakrama A1 - Taylor, Clive R. PY - 1998 T2 - Concise Pathology, 3e AB - The skeleton is composed of flat bones and long tubular bones. Flat bones such as the skull, sternum, and pelvic bones develop from fibrous tissue (through intramembranous ossification), whereas long tubular bones increase in length at a line of cartilage present near the growing bone ends known as the epiphysial plate or growth plate. Anatomic regions of long bones relate to the growth plate and include the epiphysis, which is the region between the growth plate and the nearest joint; the diaphysis, which is the shaft region of the bone between the two growth plates; and the metaphysis, which is the region of bone adjacent to the growth plate on the diaphysial side. The metaphysis is the area where new bone is laid down during growth, and in children it represents the most vascular and most metabolically active region of bone. For this reason, the metaphysial region is the area most susceptible to infections and neoplasm formation in childhood. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/11/05 UR - accessphysiotherapy.mhmedical.com/content.aspx?aid=193533 ER -