RT Book, Section A1 Funk, Janet L. A2 Hammer, Gary D. A2 McPhee, Stephen J. SR Print(0) ID 1156659591 T1 Disorders of the Endocrine Pancreas T2 Pathophysiology of Disease: An Introduction to Clinical Medicine, 8e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781260026504 LK accessphysiotherapy.mhmedical.com/content.aspx?aid=1156659591 RD 2024/04/19 AB Insulin and glucagon, the two key hormones that orchestrate fuel storage and use, are produced by the islet cells in the pancreas. Islet cells are distributed in clusters throughout the exocrine pancreas. Together, they comprise the endocrine pancreas. Diabetes mellitus, a heterogeneous disorder, is the most common disease of the endocrine pancreas. Affecting 9% of the world’s adult population in 2014, the prevalence of diabetes continues to increase worldwide, having already more than doubled over the past three decades. Pancreatic tumors secreting excessive amounts of specific islet cell hormones are far less common, but their clinical presentations underscore the important regulatory roles of each hormone.