RT Book, Section A1 Jobst, Erin E. A1 Panus, Peter C. A1 Kruidering-Hall, Marieke SR Print(0) ID 1192816551 T1 Opioid Analgesics and Antagonists T2 Pharmacology for the Physical Therapist, 2e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781259862229 LK accessphysiotherapy.mhmedical.com/content.aspx?aid=1192816551 RD 2024/04/19 AB CASE STUDYS.F. is a 58-year-old woman with a long history of bilateral knee osteoarthritis. For the past several years, conservative treatment has included physical therapy and medications (oral cyclooxygenase-2 [COX-2] inhibitors and intra-articular triamcinolone acetonide injections). Because she has had progressively more pain and dysfunction over the past year, S.F. and her primary physician determined that it was time for bilateral total knee arthroplasties (TKA). The patient subsequently underwent bilateral TKA without complication. Postsurgical inpatient pain management includes oral oxycodone and a PCA pump with morphine sulfate for breakthrough pain. Early physical therapy interventions on postoperative days 1 and 2 focused on active and passive range of motion (ROM) of both lower extremities, transfer training, and upright mobility training. Prior to surgery, S.F. stated that her goal was to discharge from the hospital directly to her home. Her strong preference is not to be admitted to a skilled nursing facility, even for a short time. In line with this goal, S.F. has eagerly and actively participated in twice-daily physical therapy sessions. She has informed the nursing staff that she has a low tolerance for pain and asks for the oral pain medication 30-45 minutes before each therapy session. Initially, S.F. tolerated ROM exercises and limited mobility training well with this “pain premedication” regimen. However, upon standing and attempting gait training on postoperative day three, S.F. experienced dizziness, diaphoresis, and became very short of breath. On the second attempt to stand, the patient experienced syncope.