RT Book, Section A1 Chandrasoma, Parakrama A1 Taylor, Clive R. SR Print(0) ID 193973 T1 Introduction T2 Concise Pathology, 3e YR 1998 FD 1998 PB The McGraw-Hill Companies PP New York, NY SN 9780838514993 LK accessphysiotherapy.mhmedical.com/content.aspx?aid=193973 RD 2024/04/19 AB All tissues in the body are composed of parenchymal cells, which are specialized to perform the functions of that particular tissue, and interstitial connective tissue elements, which act as the supporting framework of the tissue (Figure I-1). Human disease results from the action of various injurious agents on tissues. Injurious agents may act on parenchymal cells or interstitial connective tissue, causing biochemical or structural damage. Biochemical damage may result in abnormal function and disease without producing any structural alteration in tissue. Structural damage may sometimes be recognized only by microscopic examination of the tissue. In parenchymal cells, it results either in reversible changes short of cell death (cell degeneration) or in irreversible cell death (necrosis). These are discussed in Chapter 1: Cell Degeneration & Necrosis. Interstitial tissue damage results in interstitial abnormalities (Chapter 2: Abnormalities of Interstitial Tissues). Parenchymal cell damage may result from interstitial abnormalities and vice versa.