RT Book, Section A1 Chandrasoma, Parakrama A1 Taylor, Clive R. SR Print(0) ID 183201 T1 Chapter 2. Abnormalities of Interstitial Tissues T2 Concise Pathology, 3e YR 1998 FD 1998 PB The McGraw-Hill Companies PP New York, NY SN 9780838514993 LK accessphysiotherapy.mhmedical.com/content.aspx?aid=183201 RD 2021/03/03 AB The normal function of parenchymal cells is largely dependent on the integrity of the interstitial tissues that make up the immediate microenvironment of the cells. Interstitial tissue is composed of cells, water and electrolytes, ground substance, and fibrillary elements (Figure 2-1). The pH and the electrolyte composition of interstitial tissue are maintained in equilibrium both with those of plasma in capillaries and with those of the intracellular fluid compartment. The ground substances and supporting fibers of interstitial tissue are produced by specialized connective tissue cells derived from the mesoderm (mesenchymal cells), mainly fibroblasts.