RT Book, Section A1 Panus, Peter C. A1 Jobst, Erin E. A1 Masters, Susan B. A1 Katzung, Bertram A1 Tinsley, Suzanne L. A1 Trevor, Anthony J. SR Print(0) ID 6093102 T1 Chapter 22. Growth, Thyroid, and Gonadal Pharmacology T2 Pharmacology for the Physical Therapist YR 2009 FD 2009 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-146043-9 LK accessphysiotherapy.mhmedical.com/content.aspx?aid=6093102 RD 2023/02/01 AB The endocrine system integrates major organ systems with each other and with the nervous system. The endogenous ligands that the endocrine system uses to perform this integrative task are called hormones. Hormones are released from specialized cells, circulate in the blood, and regulate physiologic processes in one or more target organs. In many endocrine systems, several hormones act in series to regulate organ function. The release of one hormone in the series regulates the release of the next hormone. A series of this type provides multiple levels of regulation and integration and also provides the opportunity for negative feedback, in which the last hormone in the series can reduce the production of earlier hormones in the series and thereby regulate its own production (Figure 22–1). The endocrine system provides many useful therapeutic targets and many drugs either mimic or block the effects of naturally occurring hormones.