RT Book, Section
A1 Panus, Peter C.
A1 Jobst, Erin E.
A1 Masters, Susan B.
A1 Katzung, Bertram
A1 Tinsley, Suzanne L.
A1 Trevor, Anthony J.
SR Print(0)
ID 6093458
T1 Chapter 23. Corticosteroids and Corticosteroid Antagonists
T2 Pharmacology for the Physical Therapist
YR 2009
FD 2009
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-146043-9
LK accessphysiotherapy.mhmedical.com/content.aspx?aid=6093458
RD 2024/04/20
AB The  endogenous  corticosteroids  are  produced  by  the  adrenal  cortex  and  are  essential  for  life.  As  with  the  gonadal  steroid  hormones  discussed  in  Chapter  22,  corticosteroids  are  synthesized  from  cholesterol.  They  comprise  two  major  physiologic  and  pharmacologic  groups,  glucocorticoids  and  mineralocorticoids  (Figure  23–1).  Glucocorticoids  have  important  effects  on  intermediary  metabolism,  catabolism,  immune  responses,  and  inflammation.  Mineralocorticoids  regulate  sodium  and  potassium  transport  in  the  collecting  tubules  of  the  kidney.  A  third  group,  the  adrenal  androgens  (dehydroepiandrosterone  [DHEA]  and  androstenedione)  constitute  the  major  endogenous  precursors  of  estrogen  in  females  in  whom  ovarian  function  is  deficient  or  absent  (e.g.,  postmenopausal)  and  in  preadolescent  males.  Drugs  that  modulate  the  physiologic  effects  of  endogenous  corticosteroids  either  mimic  the  corticosteroids  or  inhibit  corticosteroid  synthesis  or  receptor  interactions.