RT Book, Section
A1 Panus, Peter C.
A1 Jobst, Erin E.
A1 Masters, Susan B.
A1 Katzung, Bertram
A1 Tinsley, Suzanne L.
A1 Trevor, Anthony J.
SR Print(0)
ID 6093731
T1 Chapter 25. Drugs That Affect Bone Mineral Homeostasis
T2 Pharmacology for the Physical Therapist
YR 2009
FD 2009
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-146043-9
LK accessphysiotherapy.mhmedical.com/content.aspx?aid=6093731
RD 2024/04/19
AB Calcium  and  phosphate  are  the  major  mineral  constituents  of  bone  and  are  also  two  of  the  most  important  minerals  for  general  cellular  function.  Accordingly,  the  body  has  evolved  a  complex  set  of  mechanisms  by  which  calcium  and  phosphate  homeostasis  is  carefully  maintained.  Approximately  98%  of  the  1  to  2  kg  of  calcium  and  85%  of  the  1  kg  of  phosphorus  in  the  human  adult  are  found  in  bone,  the  principal  reservoir  for  these  minerals.  Mineral  homeostasis  is  dynamic,  with  constant  remodeling  of  bone  and  ready  exchange  of  bone  minerals  with  free  ions  in  the  extracellular  fluid.  Bone  also  serves  as  the  principal  structural  support  for  the  body  and  provides  space  for  hematopoiesis  in  the  bone  marrow.  Abnormalities  in  bone  mineral  homeostasis  can  underlie  electrolyte  disturbances,  resulting  in  the  clinical  manifestations  of  muscle  weakness,  tetany,  and  coma.  Dysfunction  in  bone  mineral  homeostasis  can  also  disturb  the  structural  support  of  the  body  in  the  form  of  osteoporosis  and  fractures.  Hematopoietic  capacity  may  also  be  reduced  in  conditions  such  as  infantile  osteopetrosis.