RT Book, Section
A1 Toro, Camilo
A1 Hallett, Mark
A2 Watts, Ray L.
A2 Standaert, David G.
A2 Obeso, Jose A.
SR Print(0)
ID 55802229
T1 Chapter 38. Pathophysiology of Myoclonic Disorders
T2 Movement Disorders, 3e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-161312-5
LK accessphysiotherapy.mhmedical.com/content.aspx?aid=55802229
RD 2024/04/18
AB The  electrophysiological  study  of  myoclonic  movements  touches  on  the  interests  of  clinical  electrophysiologists,  epileptologists,  movement  disorders  specialists,  and  sleep  medicine  specialists  alike.  As  early  as  1935,  Gibbs  and  colleagues1  had  described  patients  with  spike-and-wave  discharges  in  the  electroencephalogram  (EEG),  with  muscle  jerking  at  the  same  rate  as  the  EEG  spikes.  Grinker  and  colleagues2  are  credited  with  the  first  description  of  polyspike  discharges  in  the  EEG,  with  close  association  to  myoclonic  jerking  in  patients  with  progressive  myoclonic  epilepsy.  In  1946,  Dawson3  produced  a  detailed  description  of  the  relationship  between  EEG  spikes  and  muscle  jerks  in  patients  with  myoclonus,  reporting  also,  in  some  of  his  patients,  the  possibility  of  inducing  myoclonic  jerks  by  tendon  tapping.  One  year  later,  Dawson  himself  demonstrated  not  only  the  first  recording  of  somatosensory-evoked  potentials  (SEPs)  from  the  scalp  in  humans,4  but  also  that  the  SEPs  in  patients  with  myoclonus  could  be  grossly  exaggerated  in  amplitude.5