RT Book, Section A1 Toro, Camilo A1 Hallett, Mark A2 Watts, Ray L. A2 Standaert, David G. A2 Obeso, Jose A. SR Print(0) ID 55802229 T1 Chapter 38. Pathophysiology of Myoclonic Disorders T2 Movement Disorders, 3e YR 2012 FD 2012 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-161312-5 LK accessphysiotherapy.mhmedical.com/content.aspx?aid=55802229 RD 2024/10/11 AB The electrophysiological study of myoclonic movements touches on the interests of clinical electrophysiologists, epileptologists, movement disorders specialists, and sleep medicine specialists alike. As early as 1935, Gibbs and colleagues1 had described patients with spike-and-wave discharges in the electroencephalogram (EEG), with muscle jerking at the same rate as the EEG spikes. Grinker and colleagues2 are credited with the first description of polyspike discharges in the EEG, with close association to myoclonic jerking in patients with progressive myoclonic epilepsy. In 1946, Dawson3 produced a detailed description of the relationship between EEG spikes and muscle jerks in patients with myoclonus, reporting also, in some of his patients, the possibility of inducing myoclonic jerks by tendon tapping. One year later, Dawson himself demonstrated not only the first recording of somatosensory-evoked potentials (SEPs) from the scalp in humans,4 but also that the SEPs in patients with myoclonus could be grossly exaggerated in amplitude.5